Cellularity of adipose depots in the genetically obese Zucker rat
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چکیده
منابع مشابه
Cellularity of adipose depots in the genetically obese Zucker rat.
Cell size and number of three adipose depots, epididymal, retroperitoneal, and subcutaneous, were determined during growth of the obese Zucker rat ("fatty") and nonobese Zucker control. Cellularity of these depots in the adult "fatty" was compared with that in nonobese controls and in nonobese Zucker rats made obese by ventromedial hypothalamic lesions. Epididymal and retroperitoneal depots in ...
متن کاملAdipose-tissue lipoprotein lipase activity and cellularity in the genetically obese Zucker rat (fa-fa).
The lipoprotein lipase activity per adipocyte was increased in the genetically obese rat (fa/fa). However, there was no difference between obese and lean animals when the enzyme activities were related to adipocyte surface area. The possible implications of the findings are discussed.
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BACKGROUND In mammals, calories ingested in excess of those used are stored primarily as fat in adipose tissue; consistent ingestion of excess calories requires an enlargement of the adipose tissue mass. Thus, a dysfunction in adipose tissue growth may be a key factor in insulin resistance due to imbalanced fat storage and disrupted insulin action. Adipose tissue growth requires the recruitment...
متن کاملStudies on the mechanism of hypertriglyceridemia in the genetically obese Zucker rat.
The possibility that impaired removal of lipoprotein triglyceride from the circulation may be a participating factor in the hypertriglyceridemia of the obese Zucker rat was examined. We found no significant differences in the heparin-released lipoprotein lipase (LPL) activities of the adipose tissue, skeletal muscle, and heart (expressed per gram of tissue) from the lean and obese Zucker rats. ...
متن کاملBrown adipose tissue thermogenesis precedes food intake in genetically obese Zucker (fa/fa) rats.
In Sprague-Dawley rats, brown adipose tissue (BAT) thermogenesis occurs in an episodic ultradian manner (BAT on-periods) as part of the basic rest-activity cycle (BRAC). Eating occurs approximately 15min after the onset of BAT on-periods. Zucker obese (fa/fa) rats eat larger less frequent meals than control rats. In chronically instrumented conscious unrestrained Zucker obese rats we examined u...
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ژورنال
عنوان ژورنال: Journal of Lipid Research
سال: 1971
ISSN: 0022-2275
DOI: 10.1016/s0022-2275(20)39459-1